RT Journal Article
SR Electronic
T1 Impact of Palliative Gastrectomy in Patients with Incurable Advanced Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1309
OP 1315
VO 28
IS 2B
A1 CHIKARA KUNISAKI
A1 HIROCHIKA MAKINO
A1 RYO TAKAGAWA
A1 TAKASHI OSHIMA
A1 YASUHIKO NAGANO
A1 SHOICHI FUJII
A1 HIROTOSHI AKIYAMA
A1 YUICHI OTSUKA
A1 HIDETAKA A. ONO
A1 TAKASHI KOSAKA
A1 YASUSHI ICHIKAWA
A1 HIROSHI SHIMADA
YR 2008
UL http://ar.iiarjournals.org/content/28/2B/1309.abstract
AB Background: The efficacy of palliative gastrectomy for incurable advanced gastric cancer remains debatable. Patients and Methods: The study group comprised a series of 164 patients who had undergone palliative gastrectomy. Survival and prognostic factors were evaluated by univariate and multivariate analyses. Results: The median survival time was 9 months. Univariate analysis identified the following as factors that adversely affected survival: larger and deeper undifferentiated tumors; peritoneal, hematogenous, or remaining lymph-node metastasis; a large number of non-curative factors; less extensive lymph-node dissection; and an absence of chemotherapy. The Cox proportional regression hazard model recognized histological type, hematogenous metastasis, peritoneal metastasis and chemotherapy as independent factors. Moreover, the number of non-curative factors independently affected the disease-specific survival. In patients with a single non-curative factor, histological type and adjuvant chemotherapy were independent prognostic factors. Conclusion: A randomized controlled study should be conducted in advanced gastric cancer patients with a single non-curative factor to confirm the usefulness of palliative gastrectomy followed by chemotherapy shown here. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved