PT  - JOURNAL ARTICLE
AU  - CHIKARA KUNISAKI
AU  - HIROCHIKA MAKINO
AU  - RYO TAKAGAWA
AU  - TAKASHI OSHIMA
AU  - YASUHIKO NAGANO
AU  - SHOICHI FUJII
AU  - HIROTOSHI AKIYAMA
AU  - YUICHI OTSUKA
AU  - HIDETAKA A. ONO
AU  - TAKASHI KOSAKA
AU  - YASUSHI ICHIKAWA
AU  - HIROSHI SHIMADA
TI  - Impact of Palliative Gastrectomy in Patients with Incurable Advanced Gastric Cancer
DP  - 2008 Mar 01
TA  - Anticancer Research
PG  - 1309--1315
VI  - 28
IP  - 2B
4099  - http://ar.iiarjournals.org/content/28/2B/1309.short
4100  - http://ar.iiarjournals.org/content/28/2B/1309.full
SO  - Anticancer Res2008 Mar 01; 28
AB  - Background: The efficacy of palliative gastrectomy for incurable advanced gastric cancer remains debatable. Patients and Methods: The study group comprised a series of 164 patients who had undergone palliative gastrectomy. Survival and prognostic factors were evaluated by univariate and multivariate analyses. Results: The median survival time was 9 months. Univariate analysis identified the following as factors that adversely affected survival: larger and deeper undifferentiated tumors; peritoneal, hematogenous, or remaining lymph-node metastasis; a large number of non-curative factors; less extensive lymph-node dissection; and an absence of chemotherapy. The Cox proportional regression hazard model recognized histological type, hematogenous metastasis, peritoneal metastasis and chemotherapy as independent factors. Moreover, the number of non-curative factors independently affected the disease-specific survival. In patients with a single non-curative factor, histological type and adjuvant chemotherapy were independent prognostic factors. Conclusion: A randomized controlled study should be conducted in advanced gastric cancer patients with a single non-curative factor to confirm the usefulness of palliative gastrectomy followed by chemotherapy shown here. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved