%0 Journal Article %A CHIKARA KUNISAKI %A HIROCHIKA MAKINO %A RYO TAKAGAWA %A TAKASHI OSHIMA %A YASUHIKO NAGANO %A SHOICHI FUJII %A HIROTOSHI AKIYAMA %A YUICHI OTSUKA %A HIDETAKA A. ONO %A TAKASHI KOSAKA %A YASUSHI ICHIKAWA %A HIROSHI SHIMADA %T Impact of Palliative Gastrectomy in Patients with Incurable Advanced Gastric Cancer %D 2008 %J Anticancer Research %P 1309-1315 %V 28 %N 2B %X Background: The efficacy of palliative gastrectomy for incurable advanced gastric cancer remains debatable. Patients and Methods: The study group comprised a series of 164 patients who had undergone palliative gastrectomy. Survival and prognostic factors were evaluated by univariate and multivariate analyses. Results: The median survival time was 9 months. Univariate analysis identified the following as factors that adversely affected survival: larger and deeper undifferentiated tumors; peritoneal, hematogenous, or remaining lymph-node metastasis; a large number of non-curative factors; less extensive lymph-node dissection; and an absence of chemotherapy. The Cox proportional regression hazard model recognized histological type, hematogenous metastasis, peritoneal metastasis and chemotherapy as independent factors. Moreover, the number of non-curative factors independently affected the disease-specific survival. In patients with a single non-curative factor, histological type and adjuvant chemotherapy were independent prognostic factors. Conclusion: A randomized controlled study should be conducted in advanced gastric cancer patients with a single non-curative factor to confirm the usefulness of palliative gastrectomy followed by chemotherapy shown here. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved %U https://ar.iiarjournals.org/content/anticanres/28/2B/1309.full.pdf