RT Journal Article
SR Electronic
T1 Weekly 24-hour Infusional 5-Fluorouracil as Initial Treatment for Advanced Gastric Cancer with Acute Disseminated Intravascular Coagulation
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1293
OP 1297
VO 28
IS 2B
A1 TA-CHEN HUANG
A1 KUN-HUEI YEH
A1 ANN-LII CHENG
A1 CHIH-HUNG HSU
YR 2008
UL http://ar.iiarjournals.org/content/28/2B/1293.abstract
AB Background: Acute disseminated intravascular coagulation (DIC) occurring in patients with advanced gastric cancer (AGC) is a rare entity with a dismal prognosis. Conventional cytotoxic chemotherapy is usually not possible. Preliminary reports have suggested that non-myelosuppressive weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and leucovorin (HDFL) may be helpful. Patients and Methods: Between 1994 and 2005, AGC patients who presented with acute DIC and were initially treated with HDFL (5-FU 2600 mg/m2 plus leucovorin 300 mg/m2, 24-h infusion weekly) were reviewed. Results: Nineteen such patients were identified. After treatment with HDFL for a median of 4 weeks, 14 patients showed a response of the acute DIC. Eight of them subsequently received HDFL-based combination chemotherapy. The median survivals for the whole group, the DIC responders, and the 8 patients receiving subsequent combination chemotherapy were 3, 6, and 8 months, respectively. Conclusion: HDFL, as a safe initial treatment for AGC patients with acute DIC, provides the opportunity for further aggressive chemotherapy. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved