%0 Journal Article %A TA-CHEN HUANG %A KUN-HUEI YEH %A ANN-LII CHENG %A CHIH-HUNG HSU %T Weekly 24-hour Infusional 5-Fluorouracil as Initial Treatment for Advanced Gastric Cancer with Acute Disseminated Intravascular Coagulation %D 2008 %J Anticancer Research %P 1293-1297 %V 28 %N 2B %X Background: Acute disseminated intravascular coagulation (DIC) occurring in patients with advanced gastric cancer (AGC) is a rare entity with a dismal prognosis. Conventional cytotoxic chemotherapy is usually not possible. Preliminary reports have suggested that non-myelosuppressive weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and leucovorin (HDFL) may be helpful. Patients and Methods: Between 1994 and 2005, AGC patients who presented with acute DIC and were initially treated with HDFL (5-FU 2600 mg/m2 plus leucovorin 300 mg/m2, 24-h infusion weekly) were reviewed. Results: Nineteen such patients were identified. After treatment with HDFL for a median of 4 weeks, 14 patients showed a response of the acute DIC. Eight of them subsequently received HDFL-based combination chemotherapy. The median survivals for the whole group, the DIC responders, and the 8 patients receiving subsequent combination chemotherapy were 3, 6, and 8 months, respectively. Conclusion: HDFL, as a safe initial treatment for AGC patients with acute DIC, provides the opportunity for further aggressive chemotherapy. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved %U https://ar.iiarjournals.org/content/anticanres/28/2B/1293.full.pdf