TY - JOUR T1 - Induction Chemotherapy Followed by Concurrent Chemoradiotherapy in Advanced Head and Neck Squamous Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 1285 LP - 1291 VL - 28 IS - 2B AU - C. BARONE AU - R. GRILLO AU - D. DONGIOVANNI AU - N. BIROCCO AU - M. RAMPINO AU - M.G. RUO REDDA AU - E. GARIBALDI AU - F. MUNOZ AU - G. PECORARI AU - A. CAVALOT AU - P. GARZINODEMO AU - L. BUFFONI AU - L. CIUFFREDA AU - U. RICARDI AU - G. CORTESINA AU - C. GIORDANO AU - M. FASOLIS AU - S. BERRONE AU - O. BERTETTO AU - M. SCHENA Y1 - 2008/03/01 UR - http://ar.iiarjournals.org/content/28/2B/1285.abstract N2 - Background: A phase II study was carried out to investigate an induction regimen with cisplatin, paclitaxel followed by radiotherapy concurrent with weekly cisplatin for locally advanced squamous cell carcinoma of the head and neck. Patients and Methods: Stage III-IV disease patients were eligible. Two cisplatin (100 mg/m2) and paclitaxel (175 mg/m2) courses were administered every 21 days followed by standard fractionated external beam radiotherapy (approximately 70 Gy), concomitant to weekly cisplatin (30 mg/m2). Results: Thirty-five patients were enrolled: over 70% had unresectable disease with bulky lesions. Grade 3-4 neutropenia developed in 14% and G3 mucositis in 23%. Locoregional control was achieved in 51%. Median time to progression and overall survival were 10,7 and 17 months respectively; 2- and 3-year survival rates were 30% and 25% respectively. Conclusion: Our induction two-drug regimen followed by chemoradiotherapy with concurrent weekly cisplatin was well tolerated with low acute toxicity and good locoregional control and survival rate. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -