PT  - JOURNAL ARTICLE
AU  - NOBUO NAGASHIMA
AU  - YOSHIFUMI NAKAYAMA
AU  - YUZURU INOUE
AU  - JUN NAGATA
AU  - KENTARO MATSUMOTO
AU  - NORITAKA MINAGAWA
AU  - TAKEFUMI KATSUKI
AU  - KAZUNORI SHIBAO
AU  - KEIJI HIRATA
AU  - TATSUHIKO SAKO
AU  - TETSUO HAMADA
AU  - NAOKI NAGATA
TI  - Prognostic Significance of the Local Expression of Interleukin-12 in Patients with Advanced Gastric Cancer
DP  - 2008 Mar 01
TA  - Anticancer Research
PG  - 1277--1283
VI  - 28
IP  - 2B
4099  - http://ar.iiarjournals.org/content/28/2B/1277.short
4100  - http://ar.iiarjournals.org/content/28/2B/1277.full
SO  - Anticancer Res2008 Mar 01; 28
AB  - Background: Interleukin (IL)-12 is a heterodimeric cytokine that exhibits potent antitumor and antimetastatic activities. Very few studies have so far investigated the local expression of IL-12 in tumor specimens of gastric cancer. The purpose of this study was to investigate the immunohistochemical expression of IL-12 in patients with gastric cancer. Patients and Methods: IL-12 was immunohistochemically stained using monoclonal anti-human IL-12 antibody (1-1A4) in surgical specimens of 117 gastric cancer patients. The IL-12-positive cell density was calculated. The relationships among the IL-12-positive cell density, clinicopathological factors and 5-year survival rate were evaluated. Results: Among the patients (n=117), the 5-year survival rate after surgery was not statistically different between the patients with high and low IL-12 positive cell-density. However, in the patients with advanced gastric cancer (n=85), those with a high IL-12-positive cell density showed a significantly better prognosis in comparison with those with a low IL-12-positive cell density (p=0.0104). A multivariate analysis indicated that the IL-12-positive cell density and TNM stage are significant prognostic factors. Conclusion: IL-12-positive cell density may be a significant independent prognostic factor in surgical specimens of advanced gastric cancer. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved