TY - JOUR T1 - Prognostic Significance of the Local Expression of Interleukin-12 in Patients with Advanced Gastric Cancer JF - Anticancer Research JO - Anticancer Res SP - 1277 LP - 1283 VL - 28 IS - 2B AU - NOBUO NAGASHIMA AU - YOSHIFUMI NAKAYAMA AU - YUZURU INOUE AU - JUN NAGATA AU - KENTARO MATSUMOTO AU - NORITAKA MINAGAWA AU - TAKEFUMI KATSUKI AU - KAZUNORI SHIBAO AU - KEIJI HIRATA AU - TATSUHIKO SAKO AU - TETSUO HAMADA AU - NAOKI NAGATA Y1 - 2008/03/01 UR - http://ar.iiarjournals.org/content/28/2B/1277.abstract N2 - Background: Interleukin (IL)-12 is a heterodimeric cytokine that exhibits potent antitumor and antimetastatic activities. Very few studies have so far investigated the local expression of IL-12 in tumor specimens of gastric cancer. The purpose of this study was to investigate the immunohistochemical expression of IL-12 in patients with gastric cancer. Patients and Methods: IL-12 was immunohistochemically stained using monoclonal anti-human IL-12 antibody (1-1A4) in surgical specimens of 117 gastric cancer patients. The IL-12-positive cell density was calculated. The relationships among the IL-12-positive cell density, clinicopathological factors and 5-year survival rate were evaluated. Results: Among the patients (n=117), the 5-year survival rate after surgery was not statistically different between the patients with high and low IL-12 positive cell-density. However, in the patients with advanced gastric cancer (n=85), those with a high IL-12-positive cell density showed a significantly better prognosis in comparison with those with a low IL-12-positive cell density (p=0.0104). A multivariate analysis indicated that the IL-12-positive cell density and TNM stage are significant prognostic factors. Conclusion: IL-12-positive cell density may be a significant independent prognostic factor in surgical specimens of advanced gastric cancer. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -