RT Journal Article
SR Electronic
T1 Gender-specific Association between Polymorphism of <em>Vascular Endothelial Growth Factor</em> (<em>VEGF</em> 936 C&gt;T) Gene and Colon Cancer in Korea
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1271
OP 1276
VO 28
IS 2B
A1 SU JIN BAE
A1 JONG WOO KIM
A1 HAEYOUN KANG
A1 SEONG GYU HWANG
A1 DOYEUN OH
A1 NAM KEUN KIM
YR 2008
UL http://ar.iiarjournals.org/content/28/2B/1271.abstract
AB Background: Angiogenesis is an essential process in the development, growth and metastasis of malignant tumors such as colon cancer. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. A case control study was carried out to determine whether there is an association between the VEGF 936C&gt;T polymorphism and colon cancer. Patients and Methods: DNA samples taken from 262 colon cancer patients and 229 healthy controls were amplified by polymerase chain reaction for the VEGF 936C&gt;T polymorphism. Results: Genotype frequencies of the VEGF 936C&gt;T polymorphism were significantly different between patient and control groups (CT+TT, odds ratio(OR): 1.524, 95% confidence interval (CI): 1.033-2.249). When stratified by gender and age, the frequencies of the T allele-bearing genotypes significantly increased risk for colon cancer in women and patients younger than 55 years (in women, OR: 1.996, 95% CI: 1.151-3.464 and in &lt;55 years, OR: 4.156, 95% CI: 1.885-9.163). In addition, this association remained in most cases with distal and proximal colon cancer. Conclusion: Our study suggests that the VEGF 936C&gt;T polymorphism might be a genetic determinant for colon cancer, at least in Koreans. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved