TY - JOUR T1 - Gender-specific Association between Polymorphism of <em>Vascular Endothelial Growth Factor</em> (<em>VEGF</em> 936 C&gt;T) Gene and Colon Cancer in Korea JF - Anticancer Research JO - Anticancer Res SP - 1271 LP - 1276 VL - 28 IS - 2B AU - SU JIN BAE AU - JONG WOO KIM AU - HAEYOUN KANG AU - SEONG GYU HWANG AU - DOYEUN OH AU - NAM KEUN KIM Y1 - 2008/03/01 UR - http://ar.iiarjournals.org/content/28/2B/1271.abstract N2 - Background: Angiogenesis is an essential process in the development, growth and metastasis of malignant tumors such as colon cancer. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. A case control study was carried out to determine whether there is an association between the VEGF 936C&gt;T polymorphism and colon cancer. Patients and Methods: DNA samples taken from 262 colon cancer patients and 229 healthy controls were amplified by polymerase chain reaction for the VEGF 936C&gt;T polymorphism. Results: Genotype frequencies of the VEGF 936C&gt;T polymorphism were significantly different between patient and control groups (CT+TT, odds ratio(OR): 1.524, 95% confidence interval (CI): 1.033-2.249). When stratified by gender and age, the frequencies of the T allele-bearing genotypes significantly increased risk for colon cancer in women and patients younger than 55 years (in women, OR: 1.996, 95% CI: 1.151-3.464 and in &lt;55 years, OR: 4.156, 95% CI: 1.885-9.163). In addition, this association remained in most cases with distal and proximal colon cancer. Conclusion: Our study suggests that the VEGF 936C&gt;T polymorphism might be a genetic determinant for colon cancer, at least in Koreans. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -