@article {BAE1271, author = {SU JIN BAE and JONG WOO KIM and HAEYOUN KANG and SEONG GYU HWANG and DOYEUN OH and NAM KEUN KIM}, title = {Gender-specific Association between Polymorphism of Vascular Endothelial Growth Factor (VEGF 936 C>T) Gene and Colon Cancer in Korea}, volume = {28}, number = {2B}, pages = {1271--1276}, year = {2008}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Angiogenesis is an essential process in the development, growth and metastasis of malignant tumors such as colon cancer. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. A case control study was carried out to determine whether there is an association between the VEGF 936C\>T polymorphism and colon cancer. Patients and Methods: DNA samples taken from 262 colon cancer patients and 229 healthy controls were amplified by polymerase chain reaction for the VEGF 936C\>T polymorphism. Results: Genotype frequencies of the VEGF 936C\>T polymorphism were significantly different between patient and control groups (CT+TT, odds ratio(OR): 1.524, 95\% confidence interval (CI): 1.033-2.249). When stratified by gender and age, the frequencies of the T allele-bearing genotypes significantly increased risk for colon cancer in women and patients younger than 55 years (in women, OR: 1.996, 95\% CI: 1.151-3.464 and in \<55 years, OR: 4.156, 95\% CI: 1.885-9.163). In addition, this association remained in most cases with distal and proximal colon cancer. Conclusion: Our study suggests that the VEGF 936C\>T polymorphism might be a genetic determinant for colon cancer, at least in Koreans. Copyright{\textcopyright} 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/28/2B/1271}, eprint = {https://ar.iiarjournals.org/content/28/2B/1271.full.pdf}, journal = {Anticancer Research} }