RT Journal Article
SR Electronic
T1 Development of Cancer in Patients with Primary Immunodeficiencies
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1263
OP 1269
VO 28
IS 2B
A1 KATERINA SALAVOURA
A1 AGGELIKI KOLIALEXI
A1 GEORGE TSANGARIS
A1 ARIADNI MAVROU
YR 2008
UL http://ar.iiarjournals.org/content/28/2B/1263.abstract
AB Primary immunodeficiencies (PIDs) are genetic disorders that predispose to frequent and severe infections, autoimmunity and cancer. The expanded life span of such patients increases the overall risk for developing cancer, which is now estimated at 4-25% . The type of malignancy depends on the primary immunodeficiency, the age of the patient and possible viral infection, suggesting that different pathogenetic mechanisms are implicated in each case. Non-Hodgkin's lymphomas predominate, accounting for 60% of cases. The PIDs known to be associated with increased incidence of malignancy are: common variable immunodeficiency, IgA deficiency and DNA repair disorders. During recent years other types have also been included, such as severe combined immunodeficiency (SCID) and Wiskott Aldrich syndrome (WAS). Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved