PT - JOURNAL ARTICLE AU - HANNA DAHLSTRAND AU - ANDERS NÄSMAN AU - MIRCEA ROMANITAN AU - DAVID LINDQUIST AU - TORBJÖRN RAMQVIST AU - TINA DALIANIS TI - Human Papillomavirus Accounts both for Increased Incidence and Better Prognosis in Tonsillar Cancer DP - 2008 Mar 01 TA - Anticancer Research PG - 1133--1138 VI - 28 IP - 2B 4099 - http://ar.iiarjournals.org/content/28/2B/1133.short 4100 - http://ar.iiarjournals.org/content/28/2B/1133.full SO - Anticancer Res2008 Mar 01; 28 AB - The aim of this review is to present the current knowledge on the status and significance of human papillomavirus (HPV) in tonsillar cancer. An increase in the incidence of tonsillar cancer has been reported and recent data suggest that this increase is due to an increased proportion of HPV in these tumours. Furthermore, patients with HPV positive cancer have been shown to have a lower risk of relapse and longer survival compared to patients with HPV-negative tonsillar cancer. Tailoring individual treatment in tonsillar cancer may be of importance in order to reduce patient suffering as well as to increase patient survival. Finally, the fact that the presence of HPV-type 16 E6 and E7 mRNA has been ascertained in tonsillar cancer suggests that HPV-16 indeed is an aetiological factor associated with the disease and that preventive vaccination for this patient group should be discussed. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved