RT Journal Article
SR Electronic
T1 The Clinicopathological and Prognostic Significance of MUC-1 Expression in Japanese Gastric Carcinomas: An Immunohistochemical Study of Tissue Microarrays
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1061
OP 1067
VO 28
IS 2A
A1 XIAO-HAN LI
A1 HUA-CHUAN ZHENG
A1 ZHI-GANG WANG
A1 HIROYUKI TAKAHASHI
A1 XIANG-HONG YANG
A1 YI-FU GUAN
A1 YASUO TAKANO
YR 2008
UL http://ar.iiarjournals.org/content/28/2A/1061.abstract
AB Background: MUC-1 is synthesized as a single polypeptide that then undergoes proteolytic cleavage, and is associated with the epidermal growth factor receptor tyrosine kinases. In malignancies, MUC-1 may function as an anti-adhesion molecule, but can also promote adhesion and presumably metastasis. Materials and Methods: Expression of MUC-1, -2, -4 and -5AC was evaluated on tissue microarrays of gastric carcinomas (n=237) and adjacent non-cancerous mucosa specimens (n=89) by immunohistochemistry and compared with clinicopathological parameters and survival time of the patients. Results: MUC-1 was found to be highly expressed in gastric carcinomas in comparison with non-cancerous mucosa (p<0.05) and positively correlated with depth of invasion, lymphatic and venous invasion, lymph node metastasis, UICC staging and MUC-4 expression (p<0.05), but not with age, tumor size, MUC-2 or MUC-5AC expression (p>0.05). Intestinal-type carcinomas showed more MUC-1 expression than their diffuse-type counterparts (p<0.05). Kaplan-Meier analysis indicated that the cumulative survival rate of patients with no MUC-1 expression was significantly higher than those with weak, moderate or strong expression in gastric carcinomas (p<0.05), but no difference was observed when tumors were stratified according to the depth of invasion (p>0.05). Cox's analysis showed three independent prognostic factors, depth of invasion, lymphatic invasion and venous invasion, to affect the relationship between MUC-1 expression and prognosis. Conclusion: Up-regulation of MUC-1 expression may be involved in pathogenesis, invasion, metastasis and differentiation of gastric carcinoma. Altered expression might therefore be employed as an indicator of pathobiological behavior of gastric carcinoma. MUC-1 expression was found to be a prognostic factor for gastric carcinoma patients, albeit not independent of parameters of invasion.