RT Journal Article SR Electronic T1 Biphenylalkylacetylhydroquinone Ethers Suppress the Proliferation of Murine B16 Melanoma Cells JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1005 OP 1012 VO 28 IS 2A A1 NICOLLE FERNANDES A1 MANFRED JUNG A1 ALI DAOUD A1 HUANBIAO MO YR 2008 UL http://ar.iiarjournals.org/content/28/2A/1005.abstract AB Hydroquinone, an activator of caspase-9 activity via reactive oxygen species, and farnesol, a post-translational down-regulator of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity suppress the growth of murine B16 melanoma cells. Our previous studies have shown that farnesyl-O-acetylhydroquinone has a markedly greater growth-suppressive activity than that predicted by the responses to the parent compounds. Perillyl alcohol, a modulator of small G-protein activity, and biphenyl compounds, activators of Fas-mediated death pathways, suppress B16 growth. A similar synergistic increase in the potency of each compound when ether-linked to acetylhydroquinone is reported. Perillyl-O-acetylhydroquinone, biphenylethyl-O-acetylhydroquinone and biphenylpropyl-O-acetylhydroquinone had dose-dependent impacts on the proliferation of B16 cells with 50% inhibitory concentration (IC50) values of 8.0, 4.2 and 1.4 μmol/L, respectively. The growth-suppression effected by biphenylpropyl-O-acetylhydroquinone was accompanied by a dose-dependent arrest at the G1/S interface of the cell cycle, an impact greater than that previously reported for farnesyl-O-acetylhydroquinone (IC50=2.5 μmol/L). These new hydroquinone derivatives may have potential in cancer chemoprevention and/or therapy.