RT Journal Article
SR Electronic
T1 Renal Function With Enfortumab Vedotin in Metastatic Urothelial Carcinoma: A Multicenter Retrospective Study in Japan
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5645
OP 5654
DO 10.21873/anticanres.17898
VO 45
IS 12
A1 KOBARI, YUKI
A1 IIZUKA, JUNPEI
A1 KONDO, HANAE
A1 ICHIOKA, MAKIKO
A1 WATANABE, SHUN
A1 NAKAMURA, KAZUTAKA
A1 NEMOTO, YUKI
A1 HORIUCHI, TOSHIHIDE
A1 MIZOGUCHI, SHINSUKE
A1 YOSHIDA, KAZUHIKO
A1 SHIMMURA, HIROAKI
A1 HASHIMOTO, YASUNOBU
A1 KONDO, TSUNENORI
A1 KOBAYASHI, HIROSHI
A1 TAKAGI, TOSHIO
YR 2025
UL http://ar.iiarjournals.org/content/45/12/5645.abstract
AB Background/Aim: Patients with metastatic urothelial carcinoma (mUC) often experience impaired renal function because of tumor invasion, nephroureterectomy, and chemotherapy. Enfortumab vedotin (EV) has been approved in Japan as a third-line treatment for advanced UC. This study aimed to assess renal function changes in patients with mUC receiving EV therapy.Patients and Methods: We retrospectively analyzed renal function changes and clinical outcomes in 63 patients with mUC who received EV following platinum-based chemotherapy and immune checkpoint inhibitors. Data were collected from five Institutions in Japan from September 2021 to September 2024.Results: The median baseline estimated glomerular filtration rate (eGFR) was 44.1 ml/min/1.73 m2. Chronic kidney disease stage remained unchanged in 54% of patients, upstaging in 17%, and downstaging in 29%. The median change rate in eGFR was 2.6%. The median overall survival was 12.0 months in the eGFR ≥45 ml/min/1.73 m2 group and 15.4 months in the eGFR <45 ml/min/1.73 m2 group. The objective response rate was 45% in the eGFR ≥45 ml/min/1.73 m2 group and 34% in the eGFR <45 ml/min/1.73 m2 group. Adverse events (AEs) of any grade occurred in 84% of patients with eGFR ≥45 and 69% of those with eGFR <45, with grade ≥3 AEs reported in 7% and 13% patients, respectively.Conclusion: EV did not significantly impair renal function in patients with mUC. Comparable efficacy and safety were observed regardless of baseline eGFR, supporting the feasibility of EV in patients with impaired renal function.