RT Journal Article
SR Electronic
T1 Prognostic Impact of Lymphangiogenesis and Lymphatic Invasion (CD105 Expression) in Small Cell Lung Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 343
OP 347
VO 28
IS 1A
A1 HARDAVELLA, GEORGIA
A1 ARKOUMANI, EVDOKIA
A1 DALAVANGA, YIOTANNA
A1 GALANIS, PETROS
A1 AGNANTIS, NIKI J.
A1 CONSTANTOPOULOS, STAVROS
A1 STEFANOU, DIMITRIOS
YR 2008
UL http://ar.iiarjournals.org/content/28/1A/343.abstract
AB Background: Lymphangiogenesis, an essential process in the metastasis of malignant tumors, has not been thoroughly studied. The possibility of using it to define subsets of patients with different prognosis in cancer could be of vital clinical importance. Materials and Methods: Fifty patients (5 women, 45 men; mean age, 64.47 years) with SCLC were retrospectively studied. Tumor specimens were stained for CD105, and intratumoral lymphatic microvessel density (ILMVD) and lymphatic invasion were determined. Results: Twenty-five patients were diagnosed with limited and 25 with extensive SCLC. All patients received chemotherapy and 32.7% radiation therapy. A direct association between ILMVD (CD105 expression) and lymphatic invasion was observed (p<0.046). CD105 expression was significantly associated with the stage of the disease (p=0.004) and the presence of metastasis (p=0.05). Conclusion: CD105 expression and lymphatic invasion correlated significantly with the clinical parameters and patient outcome, therefore, constituting an important prognostic role in SCLC.