RT Journal Article
SR Electronic
T1 Morphological Events Found at the Invading Edge of Colorectal Carcinomas in Baboons
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 193
OP 196
VO 28
IS 1A
A1 RUBIO, CARLOS A.
A1 DICK, EDWARD
A1 HUBBARD, GENE B.
YR 2008
UL http://ar.iiarjournals.org/content/28/1A/193.abstract
AB Background: Earlier studies at the growing edge of colorectal cancer (CRC) in humans and rats have shown dilated neoplastic glands, some with a thin layer of flattened tumor cells (FTCs), some lacking one or more groups of consecutive lining tumor cells (called glandular pores, GPs). Materials and Methods: The characteristics of the neoplastic glands at the invading edge of CRCs were investigated in 39 baboons. A total of 190 neoplastic glands were studied in the 38 cases of glandular-forming adenocarcinomas. Results: In the studied neoplastic glands FTCs or GPs were recorded in 44.7% (85 glands). FTCs were found in 9.5% (18 glands) and GPs in 35.3% (67 glands). Only 7.9% or 3 out of the 38 animals showed neoplastic glands with GPs in the bulk of the tumor. Conclusion: In similarity to colorectal adenocarcinomas in humans, flattened tumor cells and glandular pores were found at the invading tumor edge of colorectal adenocarcinomas in baboons. A possible mechanism of host invasion is proposed.