PT  - JOURNAL ARTICLE
AU  - ZANG, XIAO-PING
AU  - PENTO, J. THOMAS
AU  - TARI, ANA M.
TI  - Wilms' Tumor 1 Protein and Focal Adhesion Kinase Mediate Keratinocyte Growth Factor Signaling in Breast Cancer Cells
DP  - 2008 Jan 01
TA  - Anticancer Research
PG  - 133--137
VI  - 28
IP  - 1A
4099  - http://ar.iiarjournals.org/content/28/1A/133.short
4100  - http://ar.iiarjournals.org/content/28/1A/133.full
SO  - Anticancer Res2008 Jan 01; 28
AB  - Background: Keratinocyte growth factor (KGF) has been shown to induce breast cancer metastasis in animal models. cDNA microarrays have revealed that KGF increased Wilms tumor 1 (WT1) and focal adhesion kinase (FAK) expression in breast cancer cells. The role of WT1 and FAK in KGF signaling was investigated. Materials and Methods: A cell culture wounding model was used to study the effects of WT1 and FAK down-regulation on KGF-induced proliferation and motility in breast cancer cells. Results: WT1 down-regulation inhibited KGF-mediated proliferation and motility of breast cancer cells, while FAK down-regulation inhibited proliferation, but had no significant effect on cell motility. WT1 down-regulation, but not FAK down-regulation, led to Erk1,2 inactivation. Conclusion: KGF-mediated signaling employs WT1 and FAK to regulate breast cancer cell proliferation and motility and may represent therapeutic targets for the prevention of breast cancer progression.