RT Journal Article SR Electronic T1 Expression of Metallothionein I/II and Ki-67 Antigen in Graves' Disease JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 6847 OP 6853 DO 10.21873/anticanres.13059 VO 38 IS 12 A1 PAWEL DOMOSLAWSKI A1 BARTOSZ PULA A1 MATEUSZ OLBROMSKI A1 BEATA WOJTCZAK A1 TADEUSZ LUKIENCZUK A1 MARZENNA PODHORSKA-OKOLOW A1 PIOTR DZIEGIEL YR 2018 UL http://ar.iiarjournals.org/content/38/12/6847.abstract AB Background/Aim: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. Patients and Methods: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients. Results: MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients. Cytoplasmic and nuclear MT-I/II expression correlated strongly with GD (r=0.51; p<0.0001) and NG (r=0.50; p=0.0137). Cytoplasmic MT-I/II expression was significantly higher in GD (mean IRS 9.24±2.36) than in NG (mean IRS 7.13±2.51; p=0.0006) and correlated positively with Ki-67 antigen expression (r=0.28; p=0.0165). Nuclear MT-I/II expression was elevated in GD (mean 3.53±0.65) in comparison to NG (mean 2.96±0.86; p=0.028). Conclusion: MT-I/II may be a potential marker of GD in the thyroid and may be potentially involved in thyrocytes' proliferation.