RT Journal Article
SR Electronic
T1 Survivin Expression in Glioblastomas Correlates with Proliferation, but not with Apoptosis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 109
OP 118
VO 28
IS 1A
A1 MELLAI, MARTA
A1 CALDERA, VALENTINA
A1 PATRUCCO, ALESSIA
A1 ANNOVAZZI, LAURA
A1 SCHIFFER, DAVIDE
YR 2008
UL http://ar.iiarjournals.org/content/28/1A/109.abstract
AB Background: Survivin is expressed in proliferating tissues and in tumors. It is a member of the inhibitory apoptosis protein (IAP) family known to regulate mitosis and to inhibit apoptosis. It has therefore been regarded as a target for therapies. In malignant gliomas it increases with malignancy, even though in glioblastomas it does not seem to correlate with outcome. Materials and Methods: Survivin was immunohistochemically studied in 39 selected viable glioblastoma areas belonging to 20 cases which were assayed for apoptosis, using a TUNEL assay, caspase-3, poly(ADP-ribose)polymerase 1 (PARP-1), Bid (BH3-interacting domain death agonist) and with the proliferation index Ki-67/MIB-1 and mitotic index (MI). Results: A positive linear correlation was found between the survivin labelling index (LI) and the Ki-67/MIB-1 LI and MI. No inverse correlation was found with apoptosis. Conclusion: This double behavior can be attributed to mechanisms mediating survivin activity, either as a mitosis regulator and apoptosis inhibitor, and should be taken into account in therapeutic strategies using survivin.