RT Journal Article
SR Electronic
T1 A New Peritoneal Carcinomatosis Model in Cyclosporine Immunosuppressed Rats
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 105
OP 108
VO 28
IS 1A
A1 AKHTER, JAVED
A1 YAO, PENG
A1 JOHNSON, LOREENA A.
A1 RIORDAN, STEVE M.
A1 MORRIS, DAVID L.
YR 2008
UL http://ar.iiarjournals.org/content/28/1A/105.abstract
AB Colorectal cancer (CRC) cells (HT29) were injected into the intraperitoneal (i.p.) cavity of immunosuppressed male Sprague Dawley rats. Immunosuppression was achieved via a daily i.p. injection of cyclosporine 35 mg/kg/day. Three groups of rats (n=6 per group) were injected with 20, 50 or 100 million HT29 cells. All animals developed tumours indicating that this animal model may prove useful for future research in human colorectal carcinomatosis.