PT - JOURNAL ARTICLE AU - AKHTER, JAVED AU - YAO, PENG AU - JOHNSON, LOREENA A. AU - RIORDAN, STEVE M. AU - MORRIS, DAVID L. TI - A New Peritoneal Carcinomatosis Model in Cyclosporine Immunosuppressed Rats DP - 2008 Jan 01 TA - Anticancer Research PG - 105--108 VI - 28 IP - 1A 4099 - http://ar.iiarjournals.org/content/28/1A/105.short 4100 - http://ar.iiarjournals.org/content/28/1A/105.full SO - Anticancer Res2008 Jan 01; 28 AB - Colorectal cancer (CRC) cells (HT29) were injected into the intraperitoneal (i.p.) cavity of immunosuppressed male Sprague Dawley rats. Immunosuppression was achieved via a daily i.p. injection of cyclosporine 35 mg/kg/day. Three groups of rats (n=6 per group) were injected with 20, 50 or 100 million HT29 cells. All animals developed tumours indicating that this animal model may prove useful for future research in human colorectal carcinomatosis.