PT  - JOURNAL ARTICLE
AU  - MELICHAR, BOHUSLAV
AU  - KALÁBOVÁ, HANA
AU  - KRČMOVÁ, LENKA
AU  - URBÁNEK, LUBOR
AU  - HYŠPLER, RADOMÍR
AU  - MALÍŘOVÁ, EVA
AU  - SOLICHOVÁ, DAGMAR
TI  - Serum Alpha-tocopherol, Retinol and Neopterin during Paclitaxel/Carboplatin Chemotherapy
DP  - 2007 Nov 01
TA  - Anticancer Research
PG  - 4397--4401
VI  - 27
IP  - 6C
4099  - http://ar.iiarjournals.org/content/27/6C/4397.short
4100  - http://ar.iiarjournals.org/content/27/6C/4397.full
SO  - Anticancer Res2007 Nov 01; 27
AB  - Background: Disorders of antioxidant balance are considered to be involved in the toxicity associated with radiotherapy or chemotherapy. Patients and Methods: Serum alpha-tocopherol and retinol were determined, by high performance liquid chromatography, before and during therapy with a combination of paclitaxel and carboplatin in 28 patients with breast and ovarian cancer. Serum neopterin and cholesterol were measured using a radioimmunoassay and enzymatic colorimetric method, respectively. Results: Compared to pretreatment concentrations, a significant increase was observed in serum alpha-tocopherol and retinol concentrations during therapy that was associated with decreased serum neopterin concentrations. Serum alpha-tocopherol concentrations were significantly higher during therapy in patients who did not experience serious toxicity. Conclusion: An increase in alpha-tocopherol and retinol during therapy with combination paclitaxel/carboplatin may be explained by inhibition of systemic immune activation secondary to control of the tumor with effective chemotherapy. Lower alpha-tocopherol concentrations were associated with the toxicity of therapy. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved