PT  - JOURNAL ARTICLE
AU  - M. SCORSETTI
AU  - P. NAVARRIA
AU  - A. FACOETTI
AU  - P. LATTUADA
AU  - G. URSO
AU  - A. MIRANDOLA
AU  - G.M. FERRAROLI
AU  - M. ALLOISIO
AU  - G. RAVASI
TI  - Effectiveness of Stereotactic Body Radiotherapy in the Treatment of Inoperable Early-stage Lung Cancer
DP  - 2007 Sep 01
TA  - Anticancer Research
PG  - 3615--3619
VI  - 27
IP  - 5B
4099  - http://ar.iiarjournals.org/content/27/5B/3615.short
4100  - http://ar.iiarjournals.org/content/27/5B/3615.full
SO  - Anticancer Res2007 Sep 01; 27
AB  - Background: Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. Stereotactic body irradiation offers a non-invasive treatment modality for patients with early stage NSCLC who are not amenable to surgery or other invasive approaches because of their poor medical condition. Patients and Methods: Forty-three inoperable patients with NSCLC were treated with SBRT at our institution. A mean total dose of 30.5 Gy in 1-4 fractions was applied. The median follow-up duration was 14 months (range 6-36 months). Results: The actuarial survival at two years was 53%: two patients died from cancer progression whereas a further 8 patients died from comorbidities. Acute toxicity was practically absent, with 7 (16.3%) patients suffering from grade 1 symptoms and two from (4.6%) grade II effects. At the time of this report, only 1 patient had grade II and 6 patients (13.9%) grade I chronic symptoms. Conclusion: Our results compare favourably with recently published studies and confirm that stereotactic radiotherapy has the potential to produce high local control rates with a low risk of lung toxicity in patients not amenable to curative resection. The low grade of side-effects is encouraging for shortening the treatment using a greater dose per fraction. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved