TY - JOUR T1 - Iron Oxide Particle-enhanced Magnetic Resonance Imaging for Detection of Benign Lymph Nodes in the Head and Neck: How Reliable are the Results? JF - Anticancer Research JO - Anticancer Res SP - 3571 LP - 3575 VL - 27 IS - 5B AU - MEHRAN BAGHI AU - MARTIN G. MACK AU - JENS WAGENBLAST AU - MARKUS HAMBEK AU - JÖRG RIEGER AU - SOTIRIOS BISDAS AU - WOLFGANG GSTOETTNER AU - KNUT ENGELS AU - THOMAS VOGL AU - RAINALD KNECHT Y1 - 2007/09/01 UR - http://ar.iiarjournals.org/content/27/5B/3571.abstract N2 - Aim: To evaluate the accuracy of ultrasmall paramagnetic iron oxide (USPIO: Sinerem®)-enhanced MRI in patients with head and neck cancer and enlarged lymph nodes compared with current staging examinations using histology as a gold standard. Patients and Methods: Seventeen patients with a histologically proven squamous cell cancer of the head and neck (SCCHN) and different N-stages underwent a non-enhanced and a USPIO-enhanced MRI examination. Signal intensity (SI) was measured in a region of interest evaluation. Pathohistological examination was used as a reference. Results: On a patient basis, USPIO-enhanced MRI showed a higher specificity and diagnostic accuracy (94%) compared with non-enhanced MRI (53%). One patient showed a lymph node of 6 mm in the short axial diameter which was suggested as being metastatic in Sinerem®-enhanced MRI according to the enhancement pattern of Sinerem®. This patient was staged as N1 with Sinerem®-enhanced MRI. The histopathological examination did not confirm the Sinerem®-enhanced MRI result. Conclusion: The high values for the specifity and diagnostic accuracy of Sinerem®-enhanced MRI justifies further investigations with this contrast agent. USPIO-enhanced MRI could be advantageous in avoiding surgical overtreatment. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -