%0 Journal Article %A YUSUKE URASHIMA %A KATSUMASA NAKAMURA %A YOSHIYUKI SHIOYAMA %A SATORU NOMOTO %A SAIJI OHGA %A TAKASHI TOBA %A TADAMASA YOSHITAKE %A TORU CHIKUI %A TOSHIYUKI KAWAZU %A KENICHI JINGU %A HIROMI TERASHIMA %A HIROSHI HONDA %T Treatment of Early Tongue Carcinoma with Brachytherapy: Results over a 25-Year Period %D 2007 %J Anticancer Research %P 3519-3523 %V 27 %N 5B %X Background: Brachytherapy for patients with early tongue cancer is an accepted method of treatment. Patients and Methods: The records of 409 patients with T1/2N0M0 tongue cancer treated with brachytherapy between 1978 and 2004 were reviewed. Results: The overall and disease-free 5-year survival rates were 82.3% and 64.6% for patients with T1 disease, and 72.2% and 56.0% for patients with T2 disease, respectively. The 5-year nodal metastasis-free survival rates for patients treated between 1978 and 1986, 1987 and 1996, and 1997 and 2004 were 64.8%, 74.8% and 81.3% for patients with T1 disease (p=0.22), and 47.4%, 70.4% and 76.4% for patients with T2 disease (p=0.0011), respectively. The 5-year local recurrence-free survival rates for patients treated between 1978 and 1986, 1987 and 1996, and 1997 and 2004 were 91.0%, 84.0% and 96.9% for patients with T1 disease (p=0.31), and 87.6%, 83.3% and 85.8% for patients with T2 disease (p=0.90), respectively. Conclusion: The incidence rate of nodal metastasis in patients with early tongue cancer improved over the 25-year period studied, while the local recurrence-free survival rates remained stable. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved %U https://ar.iiarjournals.org/content/anticanres/27/5B/3519.full.pdf