TY - JOUR T1 - Intraoperative Radiotherapy for Locally Advanced Prostate Cancer: Treatment Technique and Ultrasound-based Analysis of Dose Distribution JF - Anticancer Research JO - Anticancer Res SP - 3471 LP - 3476 VL - 27 IS - 5B AU - ROBERTO ORECCHIA AU - BARBARA A. JERECZEK-FOSSA AU - MARIO CIOCCA AU - ANDREA VAVASSORI AU - RAFFAELLA CAMBRIA AU - FEDERICA CATTANI AU - DARIO ZERINI AU - DELIU V. MATEI AU - BERNARDO ROCCO AU - FABRIZIO VERWEIJ AU - EPIFANIO SCARDINO AU - OTTAVIO DE COBELLI Y1 - 2007/09/01 UR - http://ar.iiarjournals.org/content/27/5B/3471.abstract N2 - Background: To present the technique and dose distribution of intraoperative radiotherapy (IORT) for prostate cancer. Patients and Methods: Pelvic lymphadenectomy, prostate IORT and radical retropubic prostatectomy was performed in 11 prostate cancer patients. Prostate thickness and rectum depth were measured with intraoperative ultrasound. IORT was delivered by a mobile linear accelerator in the operating room (electron beam, 12 Gy at 90% isodose). Results: The mean preoperative probability of organ-confined disease was 10% (Memorial Sloan Kettering Cancer Center nomograms). Mean prostate thickness, width and length were 3.4 cm, 4.6 and 4.9 cm, respectively. Mean rectum depth was 3.3 cm. Mean doses to the posterior prostate capsule, 5-mm lateral prostate margins and at the subsequent uretheral stump area were 4.6 Gy, 8.7 Gy and 11.3 Gy, respectively. Maximum mean rectal dose was 4.9 Gy. Conclusion: IORT appeared a feasible approach for prostate cancer, showing a satisfactory dose coverage to the prostate bed with relatively low rectal dose. However, high variability in dose distribution calls for further study of patient selection criteria and dosimetry. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -