RT Journal Article
SR Electronic
T1 Novel Resveratrol Derivatives Induce Apoptosis and Cause Cell Cycle Arrest in Prostate Cancer Cell Lines
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3459
OP 3464
VO 27
IS 5A
A1 HORVATH, ZSUZSANNA
A1 MARIHART-FAZEKAS, SYBILLE
A1 SAIKO, PHILIPP
A1 GRUSCH, MICHAEL
A1 ÖZSÜY, MEHMET
A1 HARIK, MIKE
A1 HANDLER, NORBERT
A1 ERKER, THOMAS
A1 JAEGER, WALTER
A1 FRITZER-SZEKERES, MONIKA
A1 DJAVAN, BOB
A1 SZEKERES, THOMAS
YR 2007
UL http://ar.iiarjournals.org/content/27/5A/3459.abstract
AB Background: Resveratrol (RV), a naturally occurring phytoalexin, exerts manifold biological effects against a variety of human tumor cell lines. In this study, the cytotoxic and biological effects of novel RV derivatives were investigated in prostate cancer cells. Materials and Methods: Cytotoxicity of the compounds was assessed by clonogenic assays in PC-3, LNCaP and DU-145 human prostate cancer cell lines. Induction of apoptosis was studied by Hoechst-propidium-iodide double staining. Cell cycle phase distribution of prostate cancer cells was analyzed using flow cytometry. Results: Methoxy- and hydroxy-substituted RV derivatives exerted cytotoxic effects against all three cell lines. The most potent compounds, 3,3′,4,4′,5,5′-hexahydroxy-stilbene and 3,4,4′,5-tetramethoxy-stilbene, induced apoptosis at concentrations lower than RV and caused cell cycle arrest in the cell lines investigated. Conclusion: Introducing additional hydroxy- and methoxy-moieties to the stilbene ring of RV is capable of enhancing its cytotoxic and pro-apoptotic effects in hormone-responsive and non-responsive prostate cancer cells. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved