PT  - JOURNAL ARTICLE
AU  - HORVATH, ZSUZSANNA
AU  - MARIHART-FAZEKAS, SYBILLE
AU  - SAIKO, PHILIPP
AU  - GRUSCH, MICHAEL
AU  - ÖZSÜY, MEHMET
AU  - HARIK, MIKE
AU  - HANDLER, NORBERT
AU  - ERKER, THOMAS
AU  - JAEGER, WALTER
AU  - FRITZER-SZEKERES, MONIKA
AU  - DJAVAN, BOB
AU  - SZEKERES, THOMAS
TI  - Novel Resveratrol Derivatives Induce Apoptosis and Cause Cell Cycle Arrest in Prostate Cancer Cell Lines
DP  - 2007 Sep 01
TA  - Anticancer Research
PG  - 3459--3464
VI  - 27
IP  - 5A
4099  - http://ar.iiarjournals.org/content/27/5A/3459.short
4100  - http://ar.iiarjournals.org/content/27/5A/3459.full
SO  - Anticancer Res2007 Sep 01; 27
AB  - Background: Resveratrol (RV), a naturally occurring phytoalexin, exerts manifold biological effects against a variety of human tumor cell lines. In this study, the cytotoxic and biological effects of novel RV derivatives were investigated in prostate cancer cells. Materials and Methods: Cytotoxicity of the compounds was assessed by clonogenic assays in PC-3, LNCaP and DU-145 human prostate cancer cell lines. Induction of apoptosis was studied by Hoechst-propidium-iodide double staining. Cell cycle phase distribution of prostate cancer cells was analyzed using flow cytometry. Results: Methoxy- and hydroxy-substituted RV derivatives exerted cytotoxic effects against all three cell lines. The most potent compounds, 3,3′,4,4′,5,5′-hexahydroxy-stilbene and 3,4,4′,5-tetramethoxy-stilbene, induced apoptosis at concentrations lower than RV and caused cell cycle arrest in the cell lines investigated. Conclusion: Introducing additional hydroxy- and methoxy-moieties to the stilbene ring of RV is capable of enhancing its cytotoxic and pro-apoptotic effects in hormone-responsive and non-responsive prostate cancer cells. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved