RT Journal Article
SR Electronic
T1 <em>COX1</em> and <em>COX2</em> Polymorphisms and Gastric Cancer Risk in a Polish Population
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4243
OP 4247
VO 27
IS 6C
A1 LIFANG HOU
A1 PAOLO GRILLO
A1 ZHONG-ZHENG ZHU
A1 JOLA LISSOWSKA
A1 MEREDITH YEAGER
A1 WITOLD ZATONSKI
A1 GUANSHAN ZHU
A1 ANDREA BACCARELLI
A1 STEPHEN J. CHANOCK
A1 JOSEPH F. FRAUMENI, Jr.
A1 WONG-HO CHOW
YR 2007
UL http://ar.iiarjournals.org/content/27/6C/4243.abstract
AB Background: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. Patients and Methods: Genotypes of several variants in both COX1 (Ex7+31 C&gt;A and Ex10-4 G&gt;A) and COX2 (-765 G&gt;C, Ex10+837 T&gt;C, Ex10-90 C&gt;T, IVS5-275 T&gt;G, and IVS7+111 T&gt;C) were identified by TaqMan™ assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. Results: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. Conclusion: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved