PT - JOURNAL ARTICLE AU - LIFANG HOU AU - PAOLO GRILLO AU - ZHONG-ZHENG ZHU AU - JOLA LISSOWSKA AU - MEREDITH YEAGER AU - WITOLD ZATONSKI AU - GUANSHAN ZHU AU - ANDREA BACCARELLI AU - STEPHEN J. CHANOCK AU - JOSEPH F. FRAUMENI, Jr. AU - WONG-HO CHOW TI - <em>COX1</em> and <em>COX2</em> Polymorphisms and Gastric Cancer Risk in a Polish Population DP - 2007 Nov 01 TA - Anticancer Research PG - 4243--4247 VI - 27 IP - 6C 4099 - http://ar.iiarjournals.org/content/27/6C/4243.short 4100 - http://ar.iiarjournals.org/content/27/6C/4243.full SO - Anticancer Res2007 Nov 01; 27 AB - Background: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. Patients and Methods: Genotypes of several variants in both COX1 (Ex7+31 C&gt;A and Ex10-4 G&gt;A) and COX2 (-765 G&gt;C, Ex10+837 T&gt;C, Ex10-90 C&gt;T, IVS5-275 T&gt;G, and IVS7+111 T&gt;C) were identified by TaqMan™ assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. Results: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. Conclusion: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved