RT Journal Article
SR Electronic
T1 Antineoplastic Activity of a Series of Ferrocene-containing Alcohols
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3431
OP 3433
VO 27
IS 5A
A1 SHAGO, REBOTSAMANG F.
A1 SWARTS, JANNIE C.
A1 KREFT, ELKE
A1 VAN RENSBURG, CONSTANCE E.J.
YR 2007
UL http://ar.iiarjournals.org/content/27/5A/3431.abstract
AB Background: Often potentially good chemotherapeutic drugs find limited clinical use due to the many negative medical and physical side-effects they may exhibit. To combat these negative side-effects, new antineoplastic materials are continuously being synthesised and evaluated. Ferrocene-containing compounds under certain conditions may show appreciable anticancer activity. Some of the factors that determine this activity have been investigated. Materials and Methods: Ferrocene-containing alcohols were tested for cytotoxicity against the HeLa cancer cell line. Cell survival was measured by means of the colorometric 3-(4,5-dimethylthiazol-2-yl)-diphenyltetrazolium bromide assay. Results: The 50% lethal dosage of 4-ferrocenylbutanol was 5.72 μmol. dm-3 and for 2-ferrocenylethanol and 3-ferrocenylpropanol it was 35.0 and 17 μmol. dm-3 respectively while for ferrocenylmethanol IC50 was >100 μmol. dm-3. Conclusion: A drug activity-structural relationship exists in that ferrocenyl drugs with longer side chains are more cytotoxic. Compounds with lower ferrocenyl group formal reduction potential are also more cytotoxic. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved