RT Journal Article
SR Electronic
T1 Association of Notch and Hedgehog Pathway Activation With Prognosis in Early-stage Colorectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2129
OP 2138
DO 10.21873/anticanres.13326
VO 39
IS 4
A1 GRIGORIOS RALLIS
A1 TRIANTAFYLLIA KOLETSA
A1 ZENIA SARIDAKI
A1 KYRIAKI MANOUSOU
A1 GEORGIA-ANGELIKI KOLIOU
A1 IOANNIS KOSTOPOULOS
A1 VASSILIKI KOTOULA
A1 THOMAS MAKATSORIS
A1 HELEN P. KOUREA
A1 GEORGIA RAPTOU
A1 SOFIA CHRISAFI
A1 EPAMINONTAS SAMANTAS
A1 KLEO PAPAPARASKEVA
A1 ELISSAVET PAZARLI
A1 PAVLOS PAPAKOSTAS
A1 GEORGIA KAFIRI
A1 DAVIDE MAURI
A1 ALEXANDRA PAPOUDOU-BAI
A1 CHRISTOS CHRISTODOULOU
A1 KALLIOPI PETRAKI
A1 NIKOLAOS DOMBROS
A1 DIMITRIOS PECTASIDES
A1 GEORGE FOUNTZILAS
YR 2019
UL http://ar.iiarjournals.org/content/39/4/2129.abstract
AB Background/Aim: Early-stage colorectal cancer (CRC) carries a wide range of survival probabilities. Novel biomarkers in this setting are eagerly awaited. Cancer stem cells (CSCs) are considered one of the reasons for treatment failure. This study sought to determine whether activation of pathways governing the function of CSC's could correlate with treatment outcomes. Materials and Methods: Tumor specimens from 325 patients were analyzed with immunohistochemistry (IHC) for Hedgehog and Notch pathway activation and results were correlated with prognosis. Results: Positive Notch3 protein expression was an unfavorable prognostic factor for disease-free survival (DFS) and overall survival (OS) (HR=2.43, p=0.024 and HR=2.56, p=0.028, respectively). Activation of the Shh pathway showed univariately longer DFS (HR=0.49, p=0.032). Possible crosstalk between the two pathways was indicated. No further associations between pathway activation and outcome were evident. Conclusion: Apart from Notch 3, activation of the pathways, as indicated by IHC expression of their components, did not result in differences in terms of DFS or OS.