RT Journal Article
SR Electronic
T1 Nucleostemin Expression in Squamous Cell Carcinoma of the Head and Neck
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3279
OP 3284
VO 27
IS 5A
A1 ČADA, ZDENĚK
A1 BOUČEK, JAN
A1 DVOŘÁNKOVÁ, BAŘBORA
A1 CHOVANEC, MARTIN
A1 PLZÁK, JAN
A1 KODET, ROMAN
A1 BETKA, JAN
A1 PINOT, GIAN L.
A1 GABIUS, HANS-JOACHIM
A1 SMETANA, KAREL
YR 2007
UL http://ar.iiarjournals.org/content/27/5A/3279.abstract
AB Background: This study presents initial data on presence of nucleostemin - a nucleolar protein typical of stem cells in the normal squamous epithelium of the oropharynx and larynx - in squamous cell carcinoma originating from these epithelia. Materials and Methods: Differentiation and proliferation markers such as keratins, β-catenin, galectin-1, and Ki-67 were studied in parallel with nucleostemin for defining cell characteristics. Results: Nucleostemin was detected in nucleoli of both proliferating basal cells and terminally differentiated suprabasal cells of normal epithelium and in tumor cells. Importantly, malignant transformation was connected with a significant enlargement of nucleostemin-positive nucleoli in these cell types. Conclusion: Detection of nucleostemin in head and neck cancer cells, together with the size of nucleoli, may be important in the evaluation of tumor differentiation and biology. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved