PT  - JOURNAL ARTICLE
AU  - ČADA, ZDENĚK
AU  - BOUČEK, JAN
AU  - DVOŘÁNKOVÁ, BAŘBORA
AU  - CHOVANEC, MARTIN
AU  - PLZÁK, JAN
AU  - KODET, ROMAN
AU  - BETKA, JAN
AU  - PINOT, GIAN L.
AU  - GABIUS, HANS-JOACHIM
AU  - SMETANA, KAREL
TI  - Nucleostemin Expression in Squamous Cell Carcinoma of the Head and Neck
DP  - 2007 Sep 01
TA  - Anticancer Research
PG  - 3279--3284
VI  - 27
IP  - 5A
4099  - http://ar.iiarjournals.org/content/27/5A/3279.short
4100  - http://ar.iiarjournals.org/content/27/5A/3279.full
SO  - Anticancer Res2007 Sep 01; 27
AB  - Background: This study presents initial data on presence of nucleostemin - a nucleolar protein typical of stem cells in the normal squamous epithelium of the oropharynx and larynx - in squamous cell carcinoma originating from these epithelia. Materials and Methods: Differentiation and proliferation markers such as keratins, β-catenin, galectin-1, and Ki-67 were studied in parallel with nucleostemin for defining cell characteristics. Results: Nucleostemin was detected in nucleoli of both proliferating basal cells and terminally differentiated suprabasal cells of normal epithelium and in tumor cells. Importantly, malignant transformation was connected with a significant enlargement of nucleostemin-positive nucleoli in these cell types. Conclusion: Detection of nucleostemin in head and neck cancer cells, together with the size of nucleoli, may be important in the evaluation of tumor differentiation and biology. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved