@article {FRANSGAARD2177, author = {TINA FRANSGAARD and JESPER HALLAS and LAU CASPAR THYGESEN and ISMAIL G{\"O}GENUR}, title = {Association of Statin Use and Oncological Outcomes After Neoadjuvant Radiotherapy in Patients With Rectal Cancer}, volume = {39}, number = {4}, pages = {2177--2182}, year = {2019}, doi = {10.21873/anticanres.13332}, publisher = {International Institute of Anticancer Research}, abstract = {Aim: The aim of the study was to examine if statin exposure during neoadjuvant chemoradiotherapy improves oncological outcomes in patients with rectal cancer. Patients and Methods: The study cohort consisted of patients who were undergoing neoadjuvant chemoradiotherapy and resection for rectal cancer. The statin users were matched 1:1 with non-users using propensity score-based matching. The primary outcome of the study was disease-free survival; secondary outcomes were recurrence-free survival and all-cause mortality. Results: A total of 704 patients were included in the study. Disease-free survival was not different between the two groups [hazard ratio (HR)=0.98, 95\% confidence intervaI (CI)=0.77-1.25, p=0.88]. Both recurrence-free survival (HR=1.02, 95\% CI=0.74-1.39, p=0.92) and all-cause mortality (HR=0.92, 95\% CI=0.68-1.23, p=0.56) were similar for the two groups. Conclusion: The study does not support that statin use is associated with response to neoadjuvant chemoradiotherapy in terms of disease-free survival, recurrence-free survival or all-cause mortality.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/39/4/2177}, eprint = {https://ar.iiarjournals.org/content/39/4/2177.full.pdf}, journal = {Anticancer Research} }