RT Journal Article
SR Electronic
T1 Increased Expression and Activity of Group IIA and X Secretory Phospholipase A2 in Peritumoral <em>versus</em> Central Colon Carcinoma Tissue
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3179
OP 3185
VO 27
IS 5A
A1 TRIBLER, LINE
A1 JENSEN, LOTTE T.
A1 JØRGENSEN, KENT
A1 BRÜNNER, NILS
A1 GELB, MICHAEL H.
A1 NIELSEN, HANS JØRGEN
A1 JENSEN, SIMON S.
YR 2007
UL http://ar.iiarjournals.org/content/27/5A/3179.abstract
AB Secretory phospholipase A2 (sPLA2) type IIA and X was analyzed in tumors from 22 patients with colon adenocarcinomas in order to determine the involvement and activity of sPLA2 in colon cancer. Evaluation of immunoreactive sPLA2 IIA by Western blotting showed a significantly higher level in the periphery of the tumors, compared to central tumor regions. Increased levels of sPLA2 IIA protein correlated with a two-fold increase in sPLA2 enzymatic activity in the peripheral regions compared to central regions. Nineteen out of 22 tumors showed high levels of sPLA2 IIA, whereas 7 out of the 22 tumors showed sPLA2 type X. These data demonstrate that both sPLA2 type IIA and X are present in human colon cancer and suggest a role for sPLA2 in colon cancer tumor immunology and tumorigenesis. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved