PT  - JOURNAL ARTICLE
AU  - GUADAGNI, FIORELLA
AU  - FERRONI, PATRIZIA
AU  - PALMIROTTA, RAFFAELE
AU  - DEL MONTE, GIROLAMO
AU  - FORMICA, VINCENZO
AU  - ROSELLI, MARIO
TI  - Non-steroidal Anti-inflammatory Drugs in Cancer Prevention and Therapy
DP  - 2007 Sep 01
TA  - Anticancer Research
PG  - 3147--3162
VI  - 27
IP  - 5A
4099  - http://ar.iiarjournals.org/content/27/5A/3147.short
4100  - http://ar.iiarjournals.org/content/27/5A/3147.full
SO  - Anticancer Res2007 Sep 01; 27
AB  - Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can be regarded as an effective approach for cancer chemoprevention, as demonstrated by a bulk of clinical and experimental evidence. However, the clinical use of these drugs as chemopreventive agents is limited by many open questions about the optimal drug, dose, duration of therapy and knowledge about the mechanism(s) by which these drugs act. In particular, the recent data on cardiovascular toxicity of coxibs has posed some limitations on the use of NSAIDs for cancer chemoprevention in the general population. The situation is different in certain genetically susceptible subgroups, such as in individuals with genetic mutations associated with hereditary nonpolyposis colon cancer (HNPCC) or familiar adenomatous polyps (FAP) in whom lifetime risk increases up to 70-90% and in whom the benefit of a chemopreventive drug might justify its use even in the presence of adverse effects. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved