RT Journal Article SR Electronic T1 Development of a Vaginal Immobilization Device: A Treatment-planning Study of Carbon-ion Radiotherapy and Intensity-modulated Radiation Therapy for Uterine Cervical Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1915 OP 1921 DO 10.21873/anticanres.13300 VO 39 IS 4 A1 YOSHIKI KUBOTA A1 TATSUYA OHNO A1 MOTOHIRO KAWASHIMA A1 KAZUTOSHI MURATA A1 NORIYUKI OKONOGI A1 SHIN-EI NODA A1 KAZUHISA TSUDA A1 MAKOTO SAKAI A1 MUTSUMI TASHIRO A1 TAKASHI NAKANO YR 2019 UL http://ar.iiarjournals.org/content/39/4/1915.abstract AB Aim: We developed a vaginal immobilization device for external radiotherapy in gynaecological malignancies and evaluated its bowel dose-reduction effect during carbon-ion radiotherapy (CIRT) and intensity-modulated radiation therapy (IMRT) in patients with cervical cancer. Patients and Methods: Computed tomographic images obtained with and without the device in seven patients with cervical cancer were assessed. Treatment plans for CIRT and IMRT were generated, and dose–volume parameters (V20, V25, V35, and D2cc) of the rectum, sigmoidal colon, and bladder were evaluated. Results: The mean±standard deviation of the rectal volume in CIRT for V35 with and without the device were 2.1±2.1 and 13.6±4.4 ml, respectively, and those in IMRT were 2.0±2.2 and 13.7±3.8 ml, respectively; these values were significantly lower in CIRT and IMRT using this device. Conclusion: Using our novel vaginal immobilization device, high rectal doses were largely reduced in CIRT and IMRT.