RT Journal Article
SR Electronic
T1 VEGF-C, VEGF-D and Flt-4 in Transitional Bladder Cancer: Relationships to Clinicopathological Parameters and Long-term Survival
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3127
OP 3133
VO 27
IS 5A
A1 HERRMANN, EDWIN
A1 ELTZE, ELKE
A1 BIERER, STEFAN
A1 KÖPKE, THOMAS
A1 GÖRGE, TOBIAS
A1 NEUMANN, JÖRG
A1 HERTLE, LOTHAR
A1 WÜLFING, CHRISTIAN
YR 2007
UL http://ar.iiarjournals.org/content/27/5A/3127.abstract
AB Background: Our aim was to determine the role of the lymphangiogenic markers VEGF-C, VEGF-D and Flt-4 in transitional bladder cancer. Materials and Methods: Archival cystectomy tumor blocks of 286 patients were selected for construction of a tissue microarray (TMA). Paraffin sections were assessed immunohistochemically using polyclonal antibodies against VEGF-C, VEGF-D and Flt-4. Staining results were evaluated semiquantitatively and analyzed for their association with various clinicopathological factors. Results: There was no association of VEGF-C with histopathological parameters or clinical outcome. Patients with VEGF-D overexpression had higher pathological tumor stages (p=0.021) and regional lymph node metastasis (p=0.008). Furthermore, they had a significantly reduced disease-free survival (p=0.042). Overexpression of Flt-4 was particularly present in the subgroup of G3 and G4 tumors (p=0.001) and was associated with a shorter disease-free survival (p=0.041). In multivariate analysis, only tumor stage and lymph node metastasis were independent prognostic parameters. Conclusion: Targeting VEGF-D and Flt-4 could be a useful tool to predict and control progression of bladder cancer. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved