RT Journal Article
SR Electronic
T1 Molecular Mechanisms Regulating the Angiogenic Phenotype in Tumors: Clinical Impact in the Future
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3111
OP 3119
VO 27
IS 5A
A1 AUBRY, KARINE
A1 BARRIERE, GUILAINE
A1 CHABLE-RABINOVITCH, HELENE
A1 DUTOUR, AURELIE
A1 PARAF, FRANCOIS
A1 MONTEIL, JACQUES
A1 RIGAUD, MICHEL
YR 2007
UL http://ar.iiarjournals.org/content/27/5A/3111.abstract
AB Tumor progression depends on the angiogenic switch. In this review, we recapitulate the molecular mechanisms involved in this angiogenic switch. The rat osteosarcoma model employed would permit further studies in the sequential events leading to initial recruitment of blood vessels and could lead to development of an angiogenesis-based panel of circulating blood cells (endothelial cells, endothelial progenitor cells and accessory cells) that can be quantified and used to detect microscopic tumors or to follow the efficacy of antiangiogenic therapy. Such a result would lead to the possibility of early therapy in cancer progression. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved