RT Journal Article
SR Electronic
T1 Frequent and Specific Involvement of Changes of the p16–RB Pathway in Esophageal Neuroendocrine Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1927
OP 1934
DO 10.21873/anticanres.13302
VO 39
IS 4
A1 FUJIMASA, KOICHIRO
A1 OHIKE, NOBUYUKI
A1 NOROSE, TOMOKO
A1 ISOBE, TOMOHIDE
A1 KIKUCHI, KAZUO
A1 OTSUKA, KOJI
A1 MURAKAMI, MASAHIKO
A1 TAKIMOTO, MASAFUMI
YR 2019
UL http://ar.iiarjournals.org/content/39/4/1927.abstract
AB Aim: This study investigated the immunohistochemical expression of retinoblastoma (RB) protein and p16 protein in 10 neuroendocrine carcinomas (NECs), in comparison to two mixed-type NECs; 28 squamous cell carcinomas (SCCs), and 12 carcinosarcomas (CSs) from patients with esophageal cancer. Materials and Methods: Immunohistochemical staining was performed using the avidin-biotin complex detection method. The staining was evaluated as diffusely positive, heterogeneous (in 5-95% of tumor cells), or diffusely negative. Results: The combination of a diffuse loss of RB and the diffuse overexpression of p16, which is found in highly aggressive malignant tumors and is considered to convincingly suggest changes in the p16–RB pathway, was found in all NECs (10/10). In contrast no mixed-type NECs, one SCC and one CS showed this finding. Coexisting intraepithelial carcinoma was detected in seven NECs and only one lesion showed the combination of diffuse RB loss and p16 overexpression. Conclusion: These data suggest that changes in the p16–RB pathway were universally and specifically involved in the development and invasion of esophageal NECs and that it may be a useful diagnostic marker and a potential therapeutic target.