RT Journal Article
SR Electronic
T1 Block Copolymer Carrier Systems for Translymphatic Chemotherapy of Lymph Node Metastases
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3935
OP 3940
VO 27
IS 6B
A1 DÜNNE, ANJA A.
A1 BOERNER, HANS G.
A1 KUKULA, HILDEGARD
A1 SCHLAAD, HELMUT
A1 WIEGAND, SUSANNE
A1 WERNER, JOCHEN A.
A1 ANTONIETTI, MARKUS
YR 2007
UL http://ar.iiarjournals.org/content/27/6B/3935.abstract
AB The presence of lymph node metastases relevantly and significantly impairs disease-specific survival in patients suffering from squamous cell carcinoma of the upper aerodigestive tract. In a VX2 animal tumor model, we present an interstitial translymphatic therapeutic approach using cis-diaminedichloro-platinum(II) (CDDP) conjugated to a poly(ethylene oxide)-block-poly(lysine) (PEO-b-PLys) block copolymer tracking systems for the successful treatment of lymph node metastases. Most effective was the application of a high cargo-load CDDP tracking system (48 wt.% CDDP) curing 90% of the animals and causing only minor local side-effects. Systems containing 1 or 10 wt.% of CDDP were less effective but still cured 50% of the animals. Moreover, the administration of 1 or 10 wt.% of CDDP consistently limited tumor growth to the draining lymph nodes (50%) and prevented systemic distribution of the metastasis even with 1 wt.% CDDP load. The systems contained 0.25-0.003 mg/kg per body weight CDDP compared to 1 ml/kg per body weight as usually used for intravenous administration. This approach encourages further and more detailed research of a CDDP-based interstitial translymphatic administration of chemotherapy for lymphogenic metastasizing carcinomas in different body regions. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved