RT Journal Article
SR Electronic
T1 Expression of Syndecan-1 in Paired Samples of Normal and Malignant Breast Tissue from Postmenopausal Women
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3045
OP 3050
VO 27
IS 5A
A1 LÖFGREN, L.
A1 SAHLIN, L.
A1 JIANG, S.
A1 VON SCHOULTZ, B.
A1 FERNSTAD, R.
A1 SKOOG, L.
A1 VON SCHOULTZ, E.
YR 2007
UL http://ar.iiarjournals.org/content/27/5A/3045.abstract
AB Background: The mammary stroma is important for modulating epithelial breast cell response to sex steroid hormones. Proteoglycans, such as syndecan-1, promote the integration of cellular signals. Materials and Methods: The immunohistochemical expression of syndecan-1 and of the androgen receptor (AR) was analyzed in paired samples of cancer and adjacent normal tissue from postmenopausal women. Results: Normal and cancer tissue showed dramatic differences in the expression of syndecan-1. In malignant breast stroma, mean values were more than 10-fold higher than in normal tissue (p<0.001). There was also a marked redistribution from the epithelium to the stroma. The expression of AR was on average 2-fold higher in cancerous than in normal tissue (p<0.01).Conclusion: Breast cancer patients have very different prognoses. Syndecan-1 and the AR may be new molecular markers relevant to clinical outcome. The redistribution from the epithelium and the dramatic increase of syndecan-1 in cancerous stroma may be related to the natural history of the disease. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved