PT  - JOURNAL ARTICLE
AU  - LÖFGREN, L.
AU  - SAHLIN, L.
AU  - JIANG, S.
AU  - VON SCHOULTZ, B.
AU  - FERNSTAD, R.
AU  - SKOOG, L.
AU  - VON SCHOULTZ, E.
TI  - Expression of Syndecan-1 in Paired Samples of Normal and Malignant Breast Tissue from Postmenopausal Women
DP  - 2007 Sep 01
TA  - Anticancer Research
PG  - 3045--3050
VI  - 27
IP  - 5A
4099  - http://ar.iiarjournals.org/content/27/5A/3045.short
4100  - http://ar.iiarjournals.org/content/27/5A/3045.full
SO  - Anticancer Res2007 Sep 01; 27
AB  - Background: The mammary stroma is important for modulating epithelial breast cell response to sex steroid hormones. Proteoglycans, such as syndecan-1, promote the integration of cellular signals. Materials and Methods: The immunohistochemical expression of syndecan-1 and of the androgen receptor (AR) was analyzed in paired samples of cancer and adjacent normal tissue from postmenopausal women. Results: Normal and cancer tissue showed dramatic differences in the expression of syndecan-1. In malignant breast stroma, mean values were more than 10-fold higher than in normal tissue (p<0.001). There was also a marked redistribution from the epithelium to the stroma. The expression of AR was on average 2-fold higher in cancerous than in normal tissue (p<0.01).Conclusion: Breast cancer patients have very different prognoses. Syndecan-1 and the AR may be new molecular markers relevant to clinical outcome. The redistribution from the epithelium and the dramatic increase of syndecan-1 in cancerous stroma may be related to the natural history of the disease. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved