PT - JOURNAL ARTICLE AU - HEGE BENEDIKTE ASVALD ØLSTØRN AU - JAN ERIK PAULSEN AU - JAN ALEXANDER TI - Effects of Perinatal Exposure to Acrylamide and Glycidamide on Intestinal Tumorigenesis in <em>Min</em>/+ Mice and Their Wild-type Litter Mates DP - 2007 Nov 01 TA - Anticancer Research PG - 3855--3864 VI - 27 IP - 6B 4099 - http://ar.iiarjournals.org/content/27/6B/3855.short 4100 - http://ar.iiarjournals.org/content/27/6B/3855.full SO - Anticancer Res2007 Nov 01; 27 AB - The tumorigenic capacity of acrylamide (AA) in the intestine of C57BL/6J Min/+ mice, as well as in their wild-type (wt) litter mates was investigated. In Experiment 1, the mice were s.c. injected with 10 or 50 mg/kg body weight (bw) of AA or glycidamide (GA) at week 1 and 2 after birth. In Experiment 2, the mice were given 50 mg/kg bw/injection of AA or GA 1 week before birth to the dam, alone or in combination with exposure of the pups at week 1 and 2 after birth. Following GA exposure at week 1 and 2, the formation of small intestinal tumors in Min/+ mice increased in a dose-dependent manner (rs=0.32, p=0.008): a 1.3-fold increase in the number of tumors with 50 mg/kg bw GA compared to the controls (p&lt;0.05). In the wt litter mates, there was a dose response relationship between the GA exposure and the frequency of animals with one or more intestinal neoplasm (intestinal tumors + aberrant crypt foci) (p=0.018): at 50 mg/kg bw of GA an 8-fold induction was found compared to the controls (p=0.017). In Experiment 2, Min/+ mice exposed to GA in utero had fewer small intestinal tumors than the controls (p&lt;0.05). However, following GA exposure the number of intestinal tumors correlated positively with the number of injections (small intestine: rs=0.32, p=0.002; colon: rs=0.27, p=0.01). When exposed early in life, GA is a weak intestinal tumorigen in Min/+ mice and their wt litter mates. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved