TY - JOUR T1 - Effects of Intralesional 32-P Chromic Phosphate in Refractory Patients with Head and Neck Tumours JF - Anticancer Research JO - Anticancer Res SP - 2997 LP - 3000 VL - 27 IS - 4C AU - KYRUS A. ALIMI AU - NOSRAT FIRUSIAN AU - WOLFRAM DEMPKE Y1 - 2007/07/01 UR - http://ar.iiarjournals.org/content/27/4C/2997.abstract N2 - Background: The clinical outcome of refractory head and neck (H&N) cancer patients remains poor despite novel treatment strategies. In this pilot study the efficacy of intratumoral injection of 32-P chromic phosphate in 14 patients with refractory H&N carcinomas was investigated in terms of response rates and overall survival. Patients and Methods: Fourteen patients (median age: 59 years) with either cytostatic drug-resistant tumours or tumours known to be primarily chemotherapy-resistant were entered into the study. After sonographic determination of the tumour volume, 32-P chromic phosphate (74-444 MBq) was injected into the central part of the tumour under sonographic guidance. Follow-up investigations included serial scintigraphy, sonographic examinations and hematological studies. Results: Injection of 32-P chromic phosphate into refractory H&N tumours resulted in remarkable regression. The median survival of all patients was 7.8 months (range: 4-16). Eight patients exhibited a partial response, while 6 patients did not respond to the treatment. In 3 patients thrombocytopenia (grade I/II) was observed, but no other significant side-effects were apparent. Significant pathological and anatomical changes within the tumour tissue were demonstrated. In all cases examined, formation of a cyst within the area of central activity, surrounded by a centrifugal necrotic ring and a marginal fibrotic structure, was found. Conclusion: A lack of persistent systematic or local side-effects, as well as noteworthy efficacy, are properties of this novel regional treatment modality with 32-P chromic phosphate. This modality deserves consideration for further clinical trials. ER -