RT Journal Article
SR Electronic
T1 Study of Colorectal Cancer with Crohn's Disease
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3771
OP 3774
VO 27
IS 6A
A1 HIGASHI, DAIJIRO
A1 FUTAMI, KITARO
A1 KAWAHARA, KAZUMASA
A1 KAMITANI, TAKANORI
A1 SEKI, KASTUNORI
A1 NARITOMI, KAZUYA
A1 EGAWA, YUJI
A1 HIRANO, KENJI
A1 TAMURA, TOMOAKI
A1 TOMIYASU, TAKASHIGE
A1 ISHIBASHI, YUKIKO
A1 SIMOMURA, TAMOSTU
A1 NII, KAORI
A1 KINUGASA, TETSUSHI
YR 2007
UL http://ar.iiarjournals.org/content/27/6A/3771.abstract
AB Background: Crohn's disease (CD) cases have been increasing and prolonged cases are now frequent. In addition, in Japan, more cases with concomitant malignant disease have also recently been reported. There is a particularly high risk of cancer occurring simultaneously in the lower rectum and the anal area. Patients and Methods: Two-hundred and eighty-six patients with CD had undergone surgery at this department, up to December, 2005. We studied malignant diseases concomitant with CD, based on empirical examples. Results: Thirteen (4.5%) were cases concomitant with malignant disease: six patients had colorectal cancer, 1 had rectal carcinoid, 1 had stomach cancer, 1 had uterine cancer, 1 had thyroid cancer, 1 had skin cancer and 2 had acute leukemia. Regarding the seven cases other than colorectal cancer, they were all juvenile patients under the age of 50, except for the stomach cancer case (69 years of age). Among the 6 cases of colorectal cancer, 5 cases were anorectal cancer and 1 was lower rectal cancer. The average age was 42.8 years (30-54 years) and the average term from CD occurrence to cancer diagnosis was 208 months (69-387 months). The one case with lower rectal cancer was intramucosal cancer which did not recur after surgery. The five cases of anorectal cancer were advanced, with invasion of the adjacent organs and 2 of them were unresectable. Four cases were of the infiltrative type, and regarding the histological findings, 4 cases were cancer with mucous production and 1 case was a poorly-differentiated endocrine tumor. Four cases had a history of anal fistula, but there was no clear causal relationship. Conclusion: In Japan, prolonged CD cases have been increasing and more and more cases of malignant disease with concomitant CD have been reported. There is a particularly high risk of cancer occurring simultaneously in the lower rectum and the anal area. Therefore, careful observation, taking all appropriate diagnostic surveillance modalities into consideration, is thus believed to be important in order to achieve an early detection of such cancer. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved