RT Journal Article
SR Electronic
T1 Quantitative Assessment of Gliomas by Proton Magnetic Resonance Spectroscopy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3757
OP 3763
VO 27
IS 6A
A1 SHINYA OSHIRO
A1 HITOSHI TSUGU
A1 FUMINARI KOMATSU
A1 HIROSHI ABE
A1 HIROKAZU ONISHI
A1 TADAHIRO OHMURA
A1 MITSUTOSHI IWAASA
A1 SEISABURO SAKAMOTO
A1 TAKEO FUKUSHIMA
YR 2007
UL http://ar.iiarjournals.org/content/27/6A/3757.abstract
AB Background: Advanced magnetic resonance (MR) techniques provide physiological and metabolic information that complements the anatomical information available from conventional MR imaging. The purpose of this study was to evaluate the clinical usefulness of proton MR spectroscopy (1H-MRS) in preoperative quantitative assessment of intracranial gliomas. Patients and Methods: Eight patients with histologically verified gliomas, comprising 2 cases with glioblastoma multiforme (GBM, grade 4), 5 cases with anaplastic oligodendroglioma (AO, grade 3; high-grade glioma), and 1 case with fibrillary astrocytoma (FA, grade 2; low-grade glioma) were evaluated using the 1H-MRS protocol following conventional MR imaging, diffusion-weighted imaging (DWI), and perfusion-weighted imaging (PWI) preoperatively. Results: High-grade gliomas tended to demonstrate signal hyperintensity by DWI and higher relative cerebral blood volume (rCBV) by PWI. Increased ratios of choline (Cho) to N-acetylaspartate (NAA) (Cho/NAA) and Cho to creatine (Cr) (Cho/Cr) correlated highly with tumor malignancy. The presence of lactate and lipid was predominately detected in patients with high-grade glioma. Conclusion: The combination of multiple MR parameters, based on DWI, PWI and 1H-MRS, appears valuable for preoperatively predicting the degree of malignancy in glioma. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved